Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of high fructose consumption on plasma levels of leptin, adropin and insulin, and serum biochemical parameters in mature adult rats

Hale Ergin Egritag¹ , Seyfullah Haliloglu²

¹Department of Biochemistry, Veterinary Faculty, Burdur Mehmet Akif Ersoy University, Burdur, Turkey; ²Department of Biochemistry, Veterinary Faculty, SelÃ§uk University, Konya, Turkey.

For correspondence:- Hale Egritag Email: haleergin@mehmetakif.edu.tr

Accepted: 10 October 2022 Published: 30 November 2022

Citation: Egritag HE, Haliloglu S. Effect of high fructose consumption on plasma levels of leptin, adropin and insulin, and serum biochemical parameters in mature adult rats. Trop J Pharm Res 2022; 21(11):2397-2402 doi: 10.4314/tjpr.v21i11.19

© 2022 The authors.
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Abstract

Purpose: To determine the effect of high-fructose consumption on plasma levels of insulin, leptin, and adropin, as well as serum biochemical parameters in mature adult rats.

Methods: Sixteen (16) mature adult rats were assigned to control group (CG) and fructose group (FG). The CG was fed ad libitum with standard rat feed and drinking water, while FG was fed standard rat feed and 20 % fructose in drinking water for 8 weeks. Plasma hormonal analyses for insulin, leptin and adropin were performed by enzyme-linked immunosorbent assay (ELISA), while serum biochemical analysis was carried out with an autoanalyzer.

Results: In FG, plasma levels of insulin and leptin significantly increased, while adropin levels decreased, when compared to CG (p < 0.05). On the other hand, while serum glucose and triglycerides were significantly increased by fructose feeding, total cholesterol, HDL-C and ALT levels were decreased (p < 0.05).

Conclusion: High fructose consumption triggers metabolic syndrome in mature adult similar to young rats, resulting in hyperleptinemia and hyperinsulinemia. Moreover, high fructose consumption decreases plasma adropin levels.

Keywords: Adropin, Fructose, Insulin, Leptin